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Fibrosis
Fibrosis, a pathological wound healing is the end result of repeated injuries and chronic inflammation induced by a variety of stimulus including autoimmune reactions, allergic responses, persistent infections, chemical, radiation, and tissue injury.
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include: Lungs, Liver, Kidney, Brain , Heart and others.
Liver fibrosis
Fibrosis is the formation of an abnormally large amount of scar tissue in the liver. It occurs when the liver attempts to repair and replace damaged cells. Many conditions can damage the liver. Fibrosis itself causes no symptoms, but severe scarring can result in cirrhosis, which can cause symptoms.
肝纖維化
Kidney fibrosis
Renal fibrosis is the consequence of excessive accumulation of extracellular matrix and represents a failed wound-healing process of the kidney tissue. The pathogenesis of renal fibrosis is a progressive process that ultimately leads to end-stage renal disease.
From: Medical Epigenetics, 2016
腎纖維化
AR drugs significantly improved necrosis and inflammatory infiltrating cells in the kidney tissue treatment improved TNF-α, IL-1β, and IL-6 production after cisplatin challenge.
Non-alcoholic steatohepatitis (NASH)
Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD). NAFLD is caused by buildup of fat in the liver. When this buildup causes inflammation and damage, it is known as NASH.
TGF-β signaling in hepatocytes contributes to hepatocyte death and lipid accumulation through Smad signaling and ROS production that promote the development of NASH.
Hepatology. 2014 Feb; 59(2): 483–495.
非酒精性脂肪肝
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