Fibrosis
Fibrosis, a pathological wound healing is the end result of repeated injuries and chronic inflammation induced by a variety of stimulus including autoimmune reactions, allergic responses, persistent infections, chemical, radiation, and tissue injury.
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include: Lungs, Liver, Kidney, Brain , Heart and others.
Liver fibrosis
Fibrosis is the formation of an abnormally large amount of scar tissue in the liver. It occurs when the liver attempts to repair and replace damaged cells. Many conditions can damage the liver. Fibrosis itself causes no symptoms, but severe scarring can result in cirrhosis, which can cause symptoms.
AR Drug group significantly decrease the AST and ALT.
AR Drug Improve the increase of AST and ALT, inflammation and necrosis of liver
Arjil drugs attenuated the steatosis, inflammation and fibrosis of liver tissue of rabbit.
Kidney fibrosis
Renal fibrosis is the consequence of excessive accumulation of extracellular matrix and represents a failed wound-healing process of the kidney tissue. The pathogenesis of renal fibrosis is a progressive process that ultimately leads to end-stage renal disease.
Study on the Reversal Effect of Arjil Drug on Cisplatin-Induced Renal Fibrosis
Cisplatin-induced Renal Fibrosis Model
•Renal fibrosis was induced via multiple Intraperitoneal injections of low-dose cisplatin (CP, 5 mg/kg) at 0, 1, and 3 weeks, for a total of 3 injections.
•To analyze the effects of samples, mice were given daily intraperitoneal injections for 7 days, starting from 4 weeks after first dose of cisplatin, and sacrificed at 4 weeks (n = 6).
AR drugs significantly improved necrosis and inflammatory infiltrating cells in the kidney tissue treatment improved TNF-α, IL-1β, and IL-6 production after cisplatin challenge.
Protective effects Arjil Drugs on cisplatin-induced kidney damage in Acute kidney injuryI mice.
Histopathological examination of Acute kidney injury
Protective effects Arjil Drugs on cisplatin-induced kidney damage in Acute kidney injury mice.
Expression Levels of Renal Fibrosis-Related Genes
Effects of AR Drug(ARH) on cisplatin-induced TWEAK, α-SMA, P53 and P21 signaling expression in kidneys. Protein levels of TWEAK, α-SMA, P53 and P21 protein expression in kidney homogenates were evaluated by western blot analysis after cisplatin challenge.
Table 1. Lung index of A. camphorata Extract and Compounds on bleomycin-induced lung fibers.
Reduced Lung Dysfunction and Histopathological Changes in BLM-Induced Mice.
Masson's Trichrome staining of the lung in bleomycin-induced lung fibrosis in mice.
The administration of Arjil AH, BH, DH significantly improved necrosis and inflammatory infiltrating cells in the lung tissue treatment improved TNF-α, IL-1β, IL-6 and TGF-β production after BLM challenge (p < 0.001).
The administration of Arjil AH, BH, DH and Dex evidently suppressed the MPO activities compared with that in BLM group (p < 0.001).
